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DPSL

Humanities || History

Interferon -The Science and Selling of a Miracle Drug

Author: Toine Pieters

Master eBook ISBN10 : 0-203-48153-4

Master eBook ISBN13 : 978-0-203-48153-0

No of pages : 240

eBook Price : $206

Originally Published : 17 Dec 2004

This innovative study charts the beginnings, history and fate of Interferon - one of modern medicine''s most famous and infamous drugs. Interferon is part of the medical profession''s armoury against viral infection, cancer and MS. The story of its development and use is one of survival in the face of remarkable cycles of promise and disappointment as a miracle drug. By telling this story, Toine Pieters'' book provides insight into the research, manufacture, and marketing of new bio-molecules that mark modern medical science.
Pieters'' closely argued book adopts a multi-disciplinary approach in seeking to trace the extraordinary voyage of interferon. Through the lens of interferon''s voyage, the book explores the interaction of the broad range of actors driving medical science:
*biological and clinical researchers
*the pharmaceutical industry
*high-powered government agencies
*doctors and patients
*the media.
The book demonstrates how research on interferon led to new clinical definitions of cancer and a new rationale for therapeutic use of the drug. Interferon provides a marvellous insight into the development of one of the most controversial drugs of our time. It enhances our understanding of how medicine manufacture and marketing all played a part in pushing back the boundaries of research, from the post-penicillin era to the genetics revolution in medicine.
This study is of particular interest to undergraduates and postgraduates in the fields of History of Medicine, Pharmacology, Medical Genetics and History of Science.



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Table of contents : Introduction
1. Interferon's Birth
Starting a British/Swiss collaboration in a London laboratory
Intimate interplay between thought and action in Room 215
Writing 'Interferon'
Isaac's Interferon Kitchen
2. Shaping a New Field of Research: Investigating Interferon(s)
Interferon going public
The Antiviral Penicillin
Misinterpretation
From the brink to revival: meeting the others
Debating Interferon's mode of operation: the specificity effect
What's in a name?
The blossoming of a new subfield
3. Interferon on Trial
A partnership originating in national interests
Establishing a collaborative programme for research on Interferon
Preparations for an early trial in volunteers
Handling production and safety problems
The Lancet report
Interferon losing its momentum
No 'magic bullet'
4. Managing Differences
Portrait of a 'gift culture'
Creating a breeding-ground for standardization
An experiment in scientific communication
Safeguarding British interests
A Finnish detour
Wrestling standards
'Having to haul down one's colours'
5. About Mice, Malignancies and Experimental Therapies
Interfering with cancer
Hoping for patients to behave like laboratory mice
Mathilde Krim's Interferon lobby
Staging a workshop on Interferon in the treatment of cancer
Attempts to put Interferon on the cancer map
6. Interferon, Audiences and Cancer
Capitalizing on a growing demand for unorthodox cancer remedies
Interferon, scientists and the media
Hailing a miracle drug
Gene dreams and the inflation of expectations
Coping with an imminent black market
7. Yet Another Twist: Marketing Interferon as a Helpful Neighbour
Beyond Interferon
A drug looking for a disease
Naturalizing Interferons as biological response modifiers and cytokines
8. Interferons in Retrospect and Prospect
Patients at work
Crafting Interferon(s)
Seeking 'magic bullets'
'Doctoring' the media
Toward genetic medicine
Patients at risk?


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